Evaluation of paraoxonase1 activities and lipid profiles concentration in sera of Β-thalassemia major patients

Muthanna Medical Journal
Volume 4, Issue 1, June 2017, Pages 14-22
http://dx.doi.org/10.18081/2410-4590/2017-14-22

Research Article

Ghufran Mohammed Hussein*

*Department of Clinical Laboratory Science, Collage of Pharmacy,  Al-Qadisiyah University
Received 22 March 2017, Accepted 26 May 2017, Available online 30 May 2017
This is article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017 GH

Abstract

Determination of serum paraoxonase1 activities and lipid profiles concentration and its action in the increasing the susceptibility for atherosclerosis development in βTM patients. The study included βTM patients in addition to apparently healthy control group. The study was conducted  on 35 patients with βTM (22 males and 13 females),  aged  5 to 15 years and the control group include 31 subjects (19 males and 12 females) those are apparently healthy, aged 6 to 17 years were used as control. Blood was taken from all subjects for determination of serum paraoxonase1 activities, lipid profile, iron and ferritin concentration. The results of present study show significant drop in serum paraoxonase and arylesterase activity, LDL-cholesterol, total cholesterol, HDL-cholesterol concentration and significant increase in serum iron, ferritin and triglycerides concentration in βTM group in comparism with control (healthy) group. In conclusion, a drop in serum PON1 activities and raise serum ferritin and iron concentration are increase the susceptibility for development of atherosclerosis in βTM patients.

Keywords: β-thalassemia major; Paraoxonase-1; Lipid profiles and Atherosclerosis

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