Assessment of spirometry in patients with hypothyroidism

Muthanna Medical Journal
Volume 4, Issue 2, December 2017, Pages 75-84

Research Article

Mohammed Abed Abdulhussein¹*, Arwaa Abed Abdulhussein², Haider Jawad Aljubury³, Haider Wared

*¹Department of Medicine, Collage of Medicine, Kufa University, Iraq
²Department of Dermatology, Collage of Medicine, Muthanna University, Iraq
³Department of Medicine, Najaf health Directorate, Iraq
Received 11 February 2017, Accepted 29 June 2017, Available online 26 July 2017
This is article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2017SA


Hypothyroid is a relatively common disease worldwide. It defined as clinical state resulting from insufficient secretion of thyroid hormone due to structural and or functional impairment of thyroid hormone production. Hypothyroid affect all organ systems including respiratory system although the respiratory manifestations are seldom the major compliant in hypothyroidism. This involvement has been attributed to decrease in both expiratory and inspiratory  muscles strength , alveolar hypoventilation  and decrease in maximal breathing capacity. The objective of this study is to evaluate the spirometry in patients with hypothyroidism. A case control study was done in the period between February 2016 to March 2017 in the center of endocrinology in Al-Sadr Medical City, Najaf, Iraq. Thirty patients with hypothyroidism and thirty age and sex matched controls were recruited. Simple spirometry, oxygen saturation, anthropometric and thyroid function were performed. Hypothyroid patients showed FVC was significant lower as compared to control group while other parameters SPO2, FEV1, FEV1/FVC were statistically insignificant. Nine (30%) hypothyroid patients had restrictive pulmonary function test. SPO2, FEV1 and FEV1/FVC were significantly associated with T4 level with direct significant correlation. In conclusion, respiratory system can be affected in hypothyroid patients in a restrictive pattern.

Keywords: Spirometry; FEV1/FVC; Hypothyroidism

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