Dyslipidemia in chronic renal failure

Muthanna Medical Journal
Volume 5, Issue 2, December 2018, Pages 56-65
http://dx.doi.org/10.18081/2410-4590/2018-56-65

Research Article

Ince Mohammed Norrie*1, Ali Adnan Jabbar Alwahami

* Correspondence author: dranasmansor2013@gmail.com
¹College of Medicine, University of Al Muthanna
Received 21 Junel 2018, Accepted 25 August 2018, Available online 13 September 2018.
This is article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2018 IN

Abstract

Dyslipidaemia is a well documented and a common finding in patients with  CRF and its prevalence is higher than in general population. Lipid profile has been studied in 50 patients with CRF excluding    patients on hemodialysis or renal transplantation, and in 48 normal subjects of matched age and sex as a control. Also the proteinuria in GUE was assessed and a history of hypertension was evaluated in patients group. Dyslipidaemia was found in 80% of patients with CRF who have significantly higher s. triglyceride and VLDL-C and lower HDL-C levels than control (P value <0.0005 for triglyceride and HDL-C and < 0.005 for VLDL-C). The commonest abnormality was hypertiglyceridaemia (56%). The frequencies of other lipid abnormalities were as follows: low HDL-C level (52%), high LDL-C level (32%), and hypercholesterolaemia (22%). Among patients with abnormal lipid profile, 70% of them have hypertension, and the same percentage have proteinuria. The dyslipidaemia distributed evenly along the course of renal failure, so it can occurs in the early course of CRF as well as in the late one. In conclusion, dyslipidaemia is present in a significant number of patients with CRF regardless of the duration of renal failure; also it is significantly associated with hypertension and/or proteinuria.

Key words: Dyslipidaemia;Hypercholesterolaemia; Chronic renal failure