The role of Trace Elements (Zinc, Copper, Magnesium and Calcium) in Pregnant Women with Preeclampsia in third trimester and fetal cord blood after delivery

Basima Sh. Alghazali, Alaa Mohammed Sadiq, Nabras Nasar Hasan

Abstract

Trace element such as zinc and copper display antioxidant activity and act as peroxynitrate scavenger while others such as magnesium and calcium essential micronutrients. The aim of this study to determine the status of these elements in preeclamptic pregnant women and to find any relationship between changes in serum level of zinc, copper, magnesium and calcium in preeclamptic women and healthy women and to assess the relation to severity of the disease in Al-Najef city.  The patients included in this study were divided into two groups control group who are normotensive (50) and study group who are preeclampsia (50 patients, 31 mild preeclampsia and 19 severe preeclampsia). Parameters include age, parity, urine albumin, liver function test, renal function test and platelets count. Maternal blood aspirated and cord blood sample taken to measure serum copper, zinc, magnesium and calcium using commercial kits. There is significant decrease in the level of trace elements between the control and pre-eclamptic groups. The mean serum level of calcium, magnesium, copper and zinc between the pre-eclamptic group and control group was significantly different. It seems that these trace elements are involved in the pathogenesis of preeclampsia.

Keywords: Preeclampsia; Zinc; Copper; Magnesium; Calcium; Cord blood

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