Breast cancer: selected cytokines in the clinical presentation

Sravan Ranjan,  Anurag Sinha

Abstract
Breast cancer is among the most commonly diagnosed cancer types in women worldwide and is the second leading cause of cancer-related disease in the USA. Recent data have suggested that many cytokines may be essential roles in the pathogenesis of breast cancer. The goal of this paper is to examine the major cytokines involved in breast cancer immunotherapy and discuss their basic biology and clinical presentation. IL-1, IL-6, IL-8, IL-10, and TNF-α in patients with breast cancer (n = 63) and healthy individuals as control (n = 68). We found that there were higher levels of IL-6, IL-8, IL-10 and TNF-α in patients with breast cancer compared to healthy controls (P<0.05). We conclude that the significance of selected cytokines is potential clinical Keywords: Breast Cancer; Cytokine; Clinical markers; Immunotherapy

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