The assessment of autoantibody before clinical onset of Rheumatoid Arthritis, has been helped in establishing early diagnosis. Recent studies on RA described many inflammatory conditions that precede joints inflammations. Anti-CCP and IgM-RF were evaluated in 10-RA patients and in same number as control. Anti-CCP was detected by ELISA and IgM-RF using latex agglutination test, while the CRP was measured by latex turbi-imetric immunoassay, and the ESR was measured by Westergren method. The values of Anti-CCP antibody is more sensitive than the other tests, in 50% were positive, and 50% negative. CRP measures were fluctuated around 37% positive and 63% were negative. ESR values have been shown a significant increase in 90% positive, whereas 10% negative. RF show a significant increase by 60% positivity. The positive value was higher for anti-CCP antibodies in comparison to other markers for RA patients. Interestingly, there were not significant relation between anti-CCP antibody titers and inflammatory markers such as ESR and CRP. However, there is a tighten relation between Anti-CCP and RF had been confirmed.
Keywords: Rheumatoid Arthritis; Anti-CCP; RF