The physiological evaluations of C-reactive protein, anti-cyclic citrullinated peptide antibody and RF in the rheumatoid arthritis patients of Al-Nassyria hospital

Abstract

The assessment of autoantibody before clinical onset of Rheumatoid Arthritis, has been helped in establishing early diagnosis. Recent studies on RA described many inflammatory conditions that precede joints inflammations. Anti-CCP and IgM-RF were evaluated in 10-RA patients and in same number as control. Anti-CCP was detected by ELISA and IgM-RF using latex agglutination test, while the CRP was measured by latex turbi-imetric immunoassay, and the ESR was measured by Westergren method. The values of Anti-CCP antibody is more sensitive than the other tests, in 50% were positive, and 50% negative. CRP measures were fluctuated around 37% positive and 63% were negative. ESR values have been shown a significant increase in 90% positive, whereas 10% negative. RF show a significant increase by 60% positivity. The positive value was higher for anti-CCP antibodies in comparison to other markers for RA patients. Interestingly, there were not significant relation between anti-CCP antibody titers and inflammatory markers such as ESR and CRP. However, there is a tighten relation between Anti-CCP and RF had been confirmed. 

Keywords: Rheumatoid Arthritis; Anti-CCP; RF