Haider Hameed Mitab*¹, N. A. A. Al-Dhalmi
Received 11 January 2017, Accepted 22 April 2017, Available online 30 June 2017
Tuberculosis (TB) stands as a major public health problem worldwide. The rapid diagnosis of individuals with active TB and detection of individuals with latent TB and rapid introduction of effective treatment to prevent them from spreading of disease. The aim of study was to evaluation the IGRA in the diagnosis of TB in comparison to other tests (conventional and molecular tests) during the period from October/2015 to June/2016 in advisory clinic for respiratory diseases and thoracic in Al-Samawa city in Al- Muthanna province. Sixty sputum and blood specimens were taken in this study was conducted with randomly selected people for evaluation of immunological detection of active and non-active tuberculosis compare with control individuals by using T-Spot. TB test, compare with tuberculin skin test (TST), conventional and molecular tests. The diagnostic sensitivity and specificity that estimated for T-Spot.TB test compare to TST were 51% and 47% respectively, and ORA was 50 %. This study concludes capability of T-Spot.T B test in diagnosis of active, under- treatment and latent PTB cases with more benefit to diagnose of extra pulmonary cases. Also, the study confirmed the failure of TST test in evaluation of PTB positive and negative incidences in respect of vaccinated or non- vaccinated status.
Keywords: Tuberculosis (TB); tuberculin skin test (TST); T-Spot