Assessment of lipid profile parameters in women with benign and malignant breast tumor dyslipidemia in chronic renal failure

Muthanna Medical Journal
Volume 6, Issue 1, June 2019, Pages 13-25
http://dx.doi.org/10.18081/2410-4590/2019-1-16

Research Article

 Ameer Amer Abd¹, Anees K. Nile², Estabraq A Al-Wasiti¹, Maysoon Mahmood Hussein³

* Correspondence author: estabraqalwasiti@yahoo.com
¹Department of chemistry and biochemistry, Collage of medicine,  Al- Nahrain University
²Department of general surgery, Collage of medicine, Al- Nahrain University
³Ministry of Health and environment of Iraq, Baghdad, Iraq
Received 11 December 2018, Accepted 21 February 2019, Available online  30 March 2019
This is article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2019 EW

Abstract

The cause of breast cancer remain unknown, but numerous factors have been directly associated with increased risk of breast cancer incidence. Among them lipid profile is one of the most important risk factors that may directly associate with breast cancer prevalence and incidence. The objective of this study is to assess lipids profile parameters in women with breast tumor and investigate their role in breast tumor initiations.  A case control study was done on105 women range from 35 -70 years that had breast tumor. Lipids profile parameters were measured in   serum of women who were categorized as newly diagnosed with untreated malignant breast tumor (n=35), newly diagnosed untreated women with benign breast tumor (n=35) and comparable age healthy women that considered as a control group (n=35). There were significant increases in the levels of TC and LDL-C in patients with malignant tumor in comparison with both benign group and controls, while TG and VLDL levels were significantly elevated in patients with malignant breast tumor in comparison only with control group. Receiver Operating Characteristic (ROC) curve showed that TC and LDL-C levels showed high sensitivity and specificity with high area under curve in malignant condition. In conclusions, lipids profile parameters especially TC and LDL-C may have a direct role in breast cancer initiation, progression and metastasis.

Keywords: Lipid profile; DNA; Breast tumor; Total cholesterol

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