Ameer Amer Abd¹, Anees K. Nile², Estabraq A Al-Wasiti¹, Maysoon Mahmood Hussein³
The cause of breast cancer remain unknown, but numerous factors have been directly associated with increased risk of breast cancer incidence. Among them lipid profile is one of the most important risk factors that may directly associate with breast cancer prevalence and incidence. The objective of this study is to assess lipids profile parameters in women with breast tumor and investigate their role in breast tumor initiations. A case control study was done on105 women range from 35 -70 years that had breast tumor. Lipids profile parameters were measured in serum of women who were categorized as newly diagnosed with untreated malignant breast tumor (n=35), newly diagnosed untreated women with benign breast tumor (n=35) and comparable age healthy women that considered as a control group (n=35). There were significant increases in the levels of TC and LDL-C in patients with malignant tumor in comparison with both benign group and controls, while TG and VLDL levels were significantly elevated in patients with malignant breast tumor in comparison only with control group. Receiver Operating Characteristic (ROC) curve showed that TC and LDL-C levels showed high sensitivity and specificity with high area under curve in malignant condition. In conclusions, lipids profile parameters especially TC and LDL-C may have a direct role in breast cancer initiation, progression and metastasis.
Keywords: Lipid profile; DNA; Breast tumor; Total cholesterol