Molecular Mechanisms and Immunomodulatory Effects of Platinum Analogs on Some Genes and as Anticancer Drugs: Review Article

Muthanna Medical Journal
Volume 7, Issue 1,  2020 Page 20-26
http://dx.doi.org/10.18081/2410-4590/2020-20-26

Research Article

Dalia Abdalkader Shakur1, Suhad Faisal Hatem Al-Mugdadi2*, Inam S. Arif1

* Correspondence author: suhadhatim@yahoo.com
1Mustansiriyah University/ College of Pharmacy/ Department of Pharmacology and Toxicology, Iraq, 2Mustansiriyah University/ College of Pharmacy/Department of Clinical Laboratories sciences /Iraq
Received 25 May 2020; accepted 10 June 2020; published 13 June 2020
This is an article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited. Copyright © 2020 WK

Abstract

Platinum analogs includes cisplatin, oxaliplatin and carboplatin. Cisplatin is a chemotherapeutic drug with excellent success in the management of human malignancies. Molecular mechanism of action related to its capacity to crosslink of DNA purine bases; also, by interfere with DNA repair, leading to DNA break, and consequently lead to apoptosis in cancer cells. Cisplatin also found to have immunomodulatory properties besides its cytotoxic effect.
Keywords:Cisplatin, Cancer, Molecular and Immunomodulatory effects, Genes repair

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