Dalia Abdalkader Shakur1, Suhad Faisal Hatem Al-Mugdadi2*, Inam S. Arif1
Received 25 May 2020; accepted 10 June 2020; published 13 June 2020
Platinum analogs includes cisplatin, oxaliplatin and carboplatin. Cisplatin is a chemotherapeutic drug with excellent success in the management of human malignancies. Molecular mechanism of action related to its capacity to crosslink of DNA purine bases; also, by interfere with DNA repair, leading to DNA break, and consequently lead to apoptosis in cancer cells. Cisplatin also found to have immunomodulatory properties besides its cytotoxic effect.
Keywords:Cisplatin, Cancer, Molecular and Immunomodulatory effects, Genes repair